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The latest in NIH COVID-19 treatment research

Susan Baker, Ph.D.

However the COVID-19 vaccine is an crucial software in stopping the unfold of the virus, treatments are even now crucial to conserving life for the duration of the pandemic. National Institutes of Health and fitness (NIH)-supported researcher Susan Baker, Ph.D., research COVID-19 treatments by fundamental investigation. The investigation is aspect of NIH’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program. Dr. Baker spoke about some recent findings and what her hopes are for upcoming treatments of the virus that brings about COVID-19 and other viruses.

What is the aim of your current COVID-19 therapy investigation?

We are making an attempt to recognize new techniques to stop the virus. We are searching at repurposing present medicine and also beginning from scratch to recognize a compound that would eventually be turned into a drug to battle COVID-19. We feel antiviral medicine can be really productive, but it can consider a lengthy time to acquire them. The upside is if we recognize these kinds of a drug, it could block several distinct types of coronaviruses, not just the virus that brings about COVID-19. A wide-spectrum drug would support each in this pandemic and in opposition to upcoming emerging viruses.

Inform us about your recent investigation in COVID-19 treatments.

My collaborators screened a library of medicine that were being authorized by the Food and Drug Administration for managing other problems and determined a compound that can block the replication of SARS-CoV-two in cells. My team tested this drug and observed that it blocks 1 of the viral proteases (or viral enzymes) that is needed for replication. If this drug can be evaluated in clinical trials in patients with COVID-19, we will master if it can be utilised to treat patients in this current pandemic. When this is thrilling, there is even now a lot operate to be performed to recognize productive treatments for COVID-19.

What is your hope for the upcoming of COVID-19 therapy investigation?

I hope we can uncover an productive way to treat folks with the virus that brings about COVID-19 and lessen the incidence of severe illness. In addition, we may well be in a position to treat folks with delicate indications and limit the unfold of the virus. Stopping the unfold of the virus is crucial for holding folks out of the intensive treatment device. If somebody without indications were being to take a look at beneficial, my hope is that we could give them a drug to immediately stop the virus from spreading in that human being, or from spreading to other people.

Why is it crucial to proceed investigation on COVID-19 treatments now that vaccines are readily available?

There are a few explanations. A new variant of the COVID-19 virus could arise that readily available vaccines are not able to stop. Or a further coronavirus could arise. We want to have medicine readily available that can concentrate on the proteins shared by all coronaviruses. This drug may well block newly emerging viruses that could lead to a new pandemic. Which is why it is really crucial to keep investing in fundamental investigation to have an understanding of these difficulties and to acquire productive treatments in opposition to all coronaviruses.