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Could one woman help researchers find a cure for Alzheimer’s?

Alzheimer’s sickness is the most widespread lead to of dementia, which contributes to a drop in memory, considering, and social abilities. More than five million people today in the U.S. dwell with Alzheimer’s, which at the moment has no treatment. 

But results from a review funded by the Countrywide Institutes of Overall health supply a new course for developing a remedy.

Researchers appeared at a large, prolonged household in Colombia, South America. Quite a few users of that household have a gene change that causes Alzheimer’s signs early, generally in their 40s, relatively than just after age 65.

Of the far more than six,000 people today in the household, about 20% had this gene change. Every person who had it created challenges with considering early—except just one girl.

In contrast to her household users, this girl did not have signs until she was in her 70s. This interested the researchers, and she volunteered for brain imaging and genetic testing to assist them comprehend why her Alzheimer’s created later.

Photos of her brain showed considerably less problems than is typically observed in people today with the sickness. The results of the genetic testing have been also intriguing. It turned out that the girl had two copies of a scarce variation in the APOE gene, referred to as APOE3ch.

This discovery could go a extensive way in supporting to progress Alzheimer’s investigation, for illustration, by mimicking how this gene variation affects the brain.

“In some cases shut analysis of a single situation can direct to discovery that could have broad implications for the discipline,” claims Countrywide Institute on Ageing Director Richard J. Hodes, M.D.