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Biomarkers identified in collegiate athletes that could help predict time needed to recover from concussion

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Thursday, August 27, 2020


A collaborative review performed by scientists from the Nationwide Institutes of Overall health, Division of Defense (DOD), and numerous tutorial establishments has recognized blood biomarkers that could assistance to forecast which athletes need to have further time to get well from a athletics linked concussion. This collaboration, acknowledged as the Concussion Evaluation, Investigation, and Schooling (Care) consortium, is supported, in element, by DOD and the Nationwide Collegiate Athletic Affiliation (NCAA).

In this review, performed at a number of web-sites across the U.S., 127 male and female collegiate athletes who had sustained a athletics-linked concussion were being examined at a number of time points: shortly after personal injury, when their indicators settled, and one particular week after returning to play. Just about every athlete had also been through preseason, baseline testing.

Applying an ultrasensitive assay that can detect minute quantities of protein, the researchers examined blood serum from these athletes and recognized two blood proteins that were being linked with the size of time required by the athletes to return to play. Quantities of these two proteins, tau protein and glial fibrillary acidic protein (GFAP) were being identified to be substantially various in athletes who required significantly less or additional than fourteen times to return. Although further more analysis is required, the success of this review are an critical phase in the direction of the improvement of a check that could assistance forecast which athletes need to have additional time to get well from a concussion and resume action.

This review was posted in JAMA Community Open.


NINR Performing Scientific Director and review creator Jessica M. Gill, Ph.D., R.N., FAAN is readily available for comment.


CL Pattinson et al. Plasma Biomarker Concentrations Associated with Return to Sport Subsequent Sport-Similar Concussion in Collegiate Athletes – A Concussion Evaluation, Investigation, and Schooling (Care) Consortium Research. JAMA Community Open. 20203(eight):e2013191. doi:10.1001/jamanetworkopen.2020.13191

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